Special Issue "Oxidative Stress in Skeletal Muscle"

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Davide Gabellini
Post date: 
21/01/2020 - 16:45

Special Issue "Oxidative Stress in Skeletal Muscle"

Deadline for manuscript submissions: 31 October 2020.


Special Issue Editor

Prof. Dr. Stefania Fulle E-Mail
Guest Editor

Department of Neuroscience, Imaging and Clinical Sciences, University ”G. d’Annunzio” Chieti-Pescara, 66100 Chieti, Italy
Interests: oxidative stress; skeletal muscle; muscle stem cells; sarcopenia; antioxidant enzymes

Special Issue Information

Dear Colleagues,

The skeletal muscle is a tissue in which the generation of free radicals, including reactive oxygen species (ROS), is more pronounced. Generation of ROS represents one of the most prominent events during contractile activity, suggesting that it could affect muscle function and health. The production of ROS is often associated with the term oxidative stress, used to define a "pathological" condition. Despite, however, the ROS formation having for a long time been believed harmful, evidence is accumulating for an important role of ROS in cell signaling. It has been proposed that several factors, including ROS, are able to regulate skeletal muscle gene expression, modulating the transcriptional profile of many genes. Furthermore, some evidence is accumulating on the role of ROS also in the modulation of miRNAs involved in muscle remodeling. The cumulative oxidative damage appears to have a strong correlation with senescence and, particularly, with sarcopenia, the physiological condition of elderly skeletal muscle. Normally, there is a balance between free radicals’ production and the intrinsic repair system of the cell, which if disturbed can lead to an increase in oxidative damage to the cell. Indeed, the cells respond to oxidative stress episodes in order to prevent further tissue damage, and that failure to respond in this way is a feature of the aging process.

How do ROS act as physiological signaling molecules, though? When does oxidative stress become a harmful factor?

In this Special Issue, we invite researchers to provide original research articles and review articles regarding results in the field of oxidative stress that are negative and/or positive for skeletal muscle, with particular attention to the role of ROS, both at cellular and molecular level, at the basis of functional and homeostatic mechanisms.

As Guest Editor, I invite you to contribute to this Special Issue on “Oxidative Stress in Skeletal Muscle”. Original research reports and reviews will be published online in Antioxidants.

Prof. Dr. Stefania Fulle
Guest Editor


Manuscript Submission Information


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.



  • Oxidative stress
  • Muscle Aging
  • Skeletal muscle homeostasis
  • Antioxidant systems
  • ROS in cell signaling

Published Papers

This special issue is now open for submission.

PDF icon Invitation.pdf226.21 KB
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